Amide Hydrolysis Using Acid Or Base Master Organic Chemistry Hydrolysis of Amides Sensitive electrochemical immunosensor via amide hydrolysis by DT diaphorase combined with five redox cycling reactions ScienceDirect 11.10 Chemistry of Amides Fundamentals of Organic Chemistry Reactions of Amides a) Hydrolysis Amides can break back into the acid and amine when heated with: Strong acid Strong base Example: Amide + HO Carboxylic acid + Amine b) Reduction File:Amide hydrolysis Amidase.png Wikipedia